Shomyseh Sanjabi, Principal Investigator
Shomyseh Sanjabi is an assistant investigator at the Gladstone Institute of Virology and Immunology and the Roddenberry Center for Stem Cell Biology and Medicine, and an assistant professor in the department of Microbiology and Immunology at the University of California, San Francisco (UCSF). She earned a bachelor’s degree in microbiology and molecular genetics from the University of California, Los Angeles (UCLA) in 1997. She earned her Ph.D. in microbiology, immunology and molecular genetics in 2003 from UCLA working with Dr. Stephen Smale on molecular mechanism of NF-kB family member specificity. She was recipient of a Cancer Research Institute Postdoctoral Fellowship and did her postdoctoral training in immunobiology at Yale University with Dr. Richard Flavell studying the role of TGF-β signaling in CD8+ T cell biology. As an independent investigator, Dr. Sanjabi has led projects in several new research areas. In recognition of her unique efforts toward achieving these goals, Dr. Sanjabi has received a number of young investigator awards, including the UCSF Hellman Award, the CFAR Highly Innovative High Risk Research Award, the International AIDS Society’s Creative and Novel Ideas in HIV Research Award, NIH Director’s New Innovator Award, and California HIV/AIDS Research Program (CHRP) IDEA Award.
Email: shomyseh dot sanjabi at gladstone dot ucsf dot edu
Shahzada Khan, Postdoctoral Scholar
Shahzada is interested in understanding the cellular and molecular mechanisms of host immune responses that determine the outcome of an infection. He received his PhD in biomedical sciences from Kumamoto University, Japan and MS in microbiology from University of Dhaka, Bangladesh. Since joining the Sanjabi Lab in May 2013, he has been investigating mucosal immunity in mouse models of viral infection, and appreciates the intricate and highly coordinated interrelationship among components of innate and adoptive immune system that are critical to mount a successful antiviral response. His focus in the lab is to investigate the immunogenic and tolerogenic parameters that govern CD8 T-cell responses during mucosal LCMV infections utilizing various knockout mouse models. His research also focuses on developing a patient-specific humanized mouse model using iPS technology for studying the mechanism of viral control in HIV elite controllers, and exploring the phenotype of immune cells that harbor latent HIV in infected patients. In addition to science, he enjoys photography, green nature, long-distance driving, and movies.
Email: shahzada dot khan at gladstone dot ucsf dot edu
Irene Lew, Research Associate I
Irene grew up in San Francisco, California and received her B.S. in Biochemistry and Cell Biology with an emphasis on medicine and Molecular Biology from the University of California, San Diego. Her interests include infectious diseases, diabetes, glycobiology and Kallmann syndrome. To keep on learning about aforementioned interests, Irene joined the Sanjabi lab in June 2016. In her spare time, she enjoys playing with cats, socializing at the local boba place, and baking cookies.
Email: irene dot lew at gladstone dot ucsf dot edu
Hesham Shehata, Postdoctoral Scholar
Hesham Shehata is a postdoctoral scholar in the Sanjabi Lab. Hesham completed his dissertation at Cincinnati Children's Hospital where he investigated the effects of aging on the development and function of Natural Killer (NK) cells. Hesham is interested in defining the mechanisms through which TGF-b regulates the development and maintenance of memory T-cells, and in particular, he is interested in evaluating how TGF-b may influence the metabolic reprogramming of T-cells during memory development. In addition to his research work, Hesham enjoys participating in soccer games and horse riding.
Email: hesham dot shehata at gladstone dot ucsf dot edu
After a process that in average amounts to 400 million dollars and a decade of preclinical research, 90% of new treatments fail to surpass clinical phase 1. Considering this high rate of failure and at the same time the number of completely unanswered biomedical questions, it is evident that new preclinical models are urgently needed. As a bioengineer I am highly interested in the complexity and function of mucosal organ systems and even more determined to develop the next generation of human in vitro models through the fusion of bioengineering, mucosal immunology and stem cell biology. I aim to address fundamental questions of mucosal organogenesis and host-microbe interactions, such as chronic viral infections. During my graduate studies in biomedical technology at the Medical faculty, University of Maribor, I completed my doctoral thesis in the group of prof. Avrelija Cencic where we created one of the first human 3D stem cell models of the small intestine. We used these models successfully for the studies of host-bacterial interactions, bioavailability of bioactives and organ development. Recognizing the importance of the immune system in the development and function of mucosal organ systems, I joined the Sanjabi Lab and the Gladstone Institutes for my postdoctoral studies. In the Sanjabi lab, I am currently focusing on the interaction between epithelia, antigen presenting cells and CD8 T cells in the establishment of intestinal protective immunity against the model virus LCMV. In the future I will translate this newly acquired insight to create multicellular human preclinical models with higher in vivo relevancy and the potential to selectively study single parameters detrimental for homeostatic conditions and disease progression. Ultimately, I hope to reduce the cost and duration of time that it takes to develop new promising therapeutics, so that it can more quickly reach those who need it the most.
Email: martin dot trapecar at gladstone dot ucsf dot edu
Frank Wu, Research Associate I
Frank was born and raised in the city and county of San Francisco. He received his B.S. in Molecular, Cell, and Developmental Biology from the University of California, Santa Cruz and joined the Sanjabi Lab in March 2016. In his free time, Frank enjoys attempting to cook, photography, swimming, and volunteering at the city Syringe Access Services.
Email: frank dot wu at gladstone dot ucsf dot edu